Palm Beach Fertility Center Boca Raton Florida, led by the renowned reproductive specialist Dr. Mark Denker, is pioneering a powerful combination in assisted reproductive technology: the integration of intraovarian platelet-rich plasma (PRP) therapy with preimplantation genetic testing for aneuploidy (PGT-A). This dual approach is providing new hope for patients who have faced multiple failed IVF cycles, particularly due to poor embryo development or recurrent miscarriages. By enhancing embryo quality with PRP and ensuring genetic normalcy through PGT-A, Palm Beach Fertility Center Boca Raton Florida is increasing the odds of successful pregnancy and healthy live births.
Enhancing Embryo Quality at Palm Beach Fertility Center Boca Raton Florida
Embryo quality is a defining factor in IVF success. At Palm Beach Fertility Center Boca Raton Florida, many patients arrive after previous treatments elsewhere that yielded poor-quality or non-viable embryos. Often, these individuals suffer from diminished ovarian reserve, unexplained infertility, or repeated implantation failure. Dr. Mark Denker and his team recognize that the root of these issues often lies in the ovarian environment and the quality of the oocytes retrieved.
Intraovarian PRP, a therapy gaining traction in regenerative medicine, is being applied at Palm Beach Fertility Center Boca Raton Florida to address this issue at its source. PRP is prepared by centrifuging a sample of the patient’s own blood to isolate the platelet-rich fraction, which contains concentrated growth factors like VEGF, PDGF, IGF, and TGF-β. These factors are known to support cellular regeneration, angiogenesis, and anti-inflammatory responses.
At Palm Beach Fertility Center Boca Raton Florida, PRP is injected directly into the ovarian cortex under ultrasound guidance. Dr. Mark Denker performs this procedure during the early follicular phase of a treatment cycle, believing that it enhances the environment for follicular recruitment and development. This can result in a more robust ovarian response, a higher number of mature oocytes, and improved embryo development.
Palm Beach Fertility Center Boca Raton Florida and the Rise of PGT-A
Preimplantation genetic testing for aneuploidy (PGT-A) has transformed the way embryos are selected for transfer. Offered at Palm Beach Fertility Center Boca Raton Florida, PGT-A involves performing a biopsy on a blastocyst-stage embryo to assess its chromosomal makeup. Embryos with a normal chromosomal count—euploid embryos—are more likely to implant successfully and result in a healthy pregnancy. Aneuploid embryos, by contrast, are a major cause of failed implantation and miscarriage.
For PGT-A to be effective, patients must produce viable blastocysts in sufficient numbers. Unfortunately, many women with ovarian insufficiency or poor egg quality are unable to reach this stage. This is where PRP therapy becomes critical. Palm Beach Fertility Center Boca Raton Florida has observed that PRP treatment often increases the number of embryos developing to the blastocyst stage, making PGT-A a viable option even for patients who previously had no embryos to test.
Timing Is Everything: Coordinating PRP and IVF at Palm Beach Fertility Center Boca Raton Florida
The timing of PRP therapy is a vital element in its success. Dr. Mark Denker has found that the regenerative effects of PRP peak approximately one to two months post-injection. During this window, the ovarian tissue is most responsive to gonadotropin stimulation, and the chances of retrieving high-quality oocytes increase.
Palm Beach Fertility Center Boca Raton Florida schedules controlled ovarian stimulation (COH) cycles to coincide with this optimal post-PRP window. When IVF is timed properly, patients benefit from both the cellular rejuvenation effects of PRP and the diagnostic precision of PGT-A. This coordination significantly increases the chances of identifying a healthy embryo suitable for transfer, especially for patients who have experienced repeated IVF failures.
Palm Beach Fertility Center Boca Raton Florida Clinical Observations and Successes
Clinical experience at Palm Beach Fertility Center Boca Raton Florida strongly supports the synergistic use of PRP and PGT-A. Dr. Mark Denker has treated numerous patients who, prior to PRP, failed to produce any blastocysts or only developed embryos of poor morphological grade. Following intraovarian PRP, many of these patients achieved improved embryo development, allowing for successful biopsy and testing.
For example, in one documented case, a 41-year-old patient with two previous failed IVF cycles produced only early-stage embryos with no blastocyst formation. After receiving intraovarian PRP at Palm Beach Fertility Center Boca Raton Florida, she underwent another IVF cycle and produced three expanded blastocysts. Two were deemed euploid by PGT-A and one was transferred successfully, resulting in a confirmed pregnancy.
While anecdotal, these real-world outcomes echo findings from recent studies, including the 2025 Scientific Reports article, which demonstrated that intraovarian PRP significantly increased the number of fertilized oocytes, total blastocysts, and good quality blastocysts in a cohort of women with a history of poor embryo development.
Scientific Support and Biologic Plausibility
The mechanism by which PRP may enhance embryo quality is still under investigation, but the biological rationale is strong. The growth factors within PRP are known to stimulate angiogenesis, cellular proliferation, and possibly even the activation of dormant ovarian stem cells—oogonial stem cells (OSCs). Whether or not these stem cells are truly functional in adult human ovaries remains a topic of scientific debate. However, there is consensus that PRP improves the ovarian microenvironment, which in turn supports healthier follicle development and oocyte maturation.
Dr. Mark Denker incorporates these findings into his protocols at Palm Beach Fertility Center Boca Raton Florida, leveraging the latest research while tailoring treatment to each patient’s clinical history. His approach recognizes that while the science of PRP is still evolving, its early success rates warrant serious consideration as part of a comprehensive fertility strategy.
A Personalized and Patient-Centered Approach
Every patient who walks into Palm Beach Fertility Center Boca Raton Florida receives individualized care rooted in compassion and scientific rigor. Dr. Mark Denker reviews each case in detail to determine whether PRP and PGT-A are appropriate, especially for those with recurrent failed cycles, poor embryo quality, or advanced maternal age. The decision to proceed with PRP is never taken lightly—it is based on evidence, ovarian reserve testing, prior IVF outcomes, and patient preferences.
Patients are educated on the benefits, limitations, and potential risks of each step. Dr. Mark Denker ensures transparency throughout the process, empowering patients to make informed decisions about their treatment paths. The combination of intraovarian PRP and PGT-A is never presented as a guarantee, but rather as a strategic option with growing clinical support.
Looking Ahead: A Vision for the Future
As fertility medicine advances, Palm Beach Fertility Center Boca Raton Florida remains committed to incorporating safe, innovative therapies that are grounded in evidence. Dr. Mark Denker continues to evaluate outcomes, track success rates, and adapt protocols based on both scientific literature and in-house clinical results.
Further research will undoubtedly refine our understanding of how PRP affects the oocyte and embryo development process, and how best to pair it with genetic testing. Until then, the experience at Palm Beach Fertility Center Boca Raton Florida suggests that patients who undergo IVF one to two months following PRP have a significantly greater chance of producing high-quality blastocysts eligible for PGT-A. This, in turn, enhances the odds of transferring a chromosomally normal embryo and achieving a live birth.
Conclusion: A Synergistic Solution for IVF Success
Palm Beach Fertility Center Boca Raton Florida has emerged as a leader in combining intraovarian PRP and PGT-A to improve embryo quality and increase the chances of a successful pregnancy. Under the expert care of Dr. Mark Denker, patients with a history of poor IVF outcomes are now finding renewed hope. By enhancing the ovarian response with PRP and selecting the healthiest embryos through PGT-A, this innovative approach is redefining what’s possible in fertility treatment. The future of reproductive medicine is here—and it’s being shaped every day at Palm Beach Fertility Center Boca Raton Florida by the vision and expertise of Dr. Mark Denker.
